Nickel-Catalyzed Enantioselective Synthesis of Pre-Differentiated Homoallylic <i>syn</i>- or <i>anti</i>-1,2-Diols from Aldehydes and Dienol Ethers
Thomas Q. Davies, John J. Murphy, Maxime Dousset, Alois Fürstner
Abstract
diastereomers of the products can be accessed depending on the configuration of the diene partner with usually excellent diastereo- and enantioselectivity.
Topics & Concepts
ChemistryRegioselectivityEnantioselective synthesisDieneNucleophileSubstituentCatalysisVicinalPhosphoramiditeDiastereomerNickelStereochemistryDiolMoietyOrganic chemistryMedicinal chemistryBiochemistryNatural rubberDNAOligonucleotideAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods