Quinoline–sulfonamides as a multi-targeting neurotherapeutic for cognitive decline: <i>in vitro</i> , <i>in silico</i> studies and ADME evaluation of monoamine oxidases and cholinesterases inhibitors
Saquib Jalil, Zahid Hussain, Syed Mobashir Ali Abid, Abdul Hameed, Jamshed Iqbal
Abstract
component, unveiling critical interactions, specifically the hydrogen bonding interaction, π-π, π-alkyl, π-amid and π-sulfur interactions between the ligand and enzymes. These findings suggest that compounds a5, a6, a11, a12, a15, and a18 may be potent multifunctional candidates for AD treatment.
Topics & Concepts
ADMEIn silicoMonoamine oxidaseMonoamine neurotransmitterChemistryQuinolinePharmacologyIn vitroEnzymeMedicineBiochemistryOrganic chemistrySerotoninReceptorGeneCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsMedicinal Plants and Neuroprotection