E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation
Liu Liu, Le Yu, Cheng Zeng, Hua Long, Guangjie Duan, Guobing Yin, Xiaotian Dai, Zhenghong Lin
Abstract
Of note, we observed that SIRT2 expression is downregulated in human lung cancer and also negatively correlates with HRD1 expression in these cancers. Additionally, we found that patients with lung adenocarcinoma having lower HRD1 or higher SIRT2 expression levels tend to survive longer. On the basis of these results, we propose a mechanism of lung tumorigenesis that involves HRD1-mediated downregulation of SIRT2 and suggest that interventions targeting HRD1 activity could be a potential therapeutic strategy to treat patients with lung cancer.
Topics & Concepts
Ubiquitin ligaseBiologyUbiquitinSirtuin 1SirtuinUbiquitin-Protein LigasesCarcinogenesisCell biologyDegradation (telecommunications)Cancer researchGeneticsDownregulation and upregulationCancerGeneAcetylationComputer scienceTelecommunicationsAutophagy in Disease and TherapySirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research