Evidence-based guidelines for the pharmacological treatment of migraine, summary version
Raffaele Ornello, Valeria Caponnetto, Fayyaz Ahmed, Haidar M. Al‐Khazali, Anna Ambrosini, Sait Ashina, Carlo Baraldi, Alessia Bellotti, Filippo Brighina, Paolo Calabresi, Francesco Casillo, Sabina Cevoli, Shuli Cheng, Chia‐Chun Chiang, Alberto Chiarugi, Rune Häckert Christensen, Min Kyung Chu, Gianluca Coppola, Ilenia Corbelli, Santiago Crema, Roberto De Icco, Marina de Tommaso, Cherubino Di Lorenzo, Vincenzo Di Stefano, Hans‐Christoph Diener, Esme Ekizoğlu, Adriana Fallacara, Valentina Favoni, Kimberly Garces, Pierangelo Geppetti, María Teresa Goicochea, Antonio Granato, Franco Granella, Simona Guérzoni, Woo‐Seok Ha, Amr Hassan, Koichi Hirata, Jan Hoffmann, Eva-Maria Hüssler, Mona Hussein, Luigi Francesco Iannone, Bronwyn Jenkins, Alejandro Labastida‐Ramírez, Anna Laporta, Morris Levin, Antonino Lupica, Edoardo Mampreso, Daniele Martinelli, Teshamae Monteith, Ilaria Orologio, Aynur Özge, Li‐Ling Hope Pan, Lavindren Luke Panneerchelvam, Mário Fernando Prieto Peres, Marcio Nattan Portes Souza, Patricia Pozo‐Rosich, Maria Pia Prudenzano, Silvia Quattrocchi, Innocenzo Rainero, V.I. Romanenko, Marina Romozzi, Antonio Russo, Grazia Sances, Paola Sarchielli, Todd J. Schwedt, Marcello Silvestro, Diego Belandrino Swerts, Cristina Tassorelli, Alessandro Tessitore, Mansoureh Togha, Gloria Vaghi, Shuu‐Jiun Wang, Messoud Ashina, Simona Sacco
Abstract
We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the GRADE approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.