Phosphotransferase System Uptake and Metabolism of the β-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection
Rezia Era D. Braza, Aliyah B. Silver, Ganesh S. Sundar, Sarah Davis, Afrooz Razi, Emrul Islam, Meaghan T. Hart, Jinyi C. Zhu, Yoann Le Breton, Kevin S. McIver
Abstract
was necessary for growth in other non-β-glucoside PTS sugars, such as fructose and mannose. Additionally, loss of BglP and BglB suggests that they are important for the regulation of virulence-related genes that control biofilm formation, streptolysin S (SLS)-mediated hemolysis, and localized ulcerative lesion progression during subcutaneous infections in mice. Thus, our results indicate that the β-glucoside PTS transports salicin and its metabolism can differentially influence GAS pathophysiology during soft tissue infection.
Topics & Concepts
PEP group translocationBiologyStreptococcus pyogenesMicrobiologyStreptococcusPermeasePhosphotransferaseSalicinPathogenGroup APhosphorylationMutantBacteriaBiochemistryGeneGeneticsInternal medicineMedicineStaphylococcus aureusStreptococcal Infections and TreatmentsAntimicrobial Resistance in StaphylococcusNeonatal and Maternal Infections