In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 <sup>+</sup> T <sub>H</sub> 1 cell response
Aurélien Sutra Del Galy, Silvia Menegatti, Jaime R. Fuentealba, Francesca Lucibello, Laëtitia Perrin, Julie Helft, Aurélie Darbois, Michael Saitakis, Jimena Tosello, Derek C. Rookhuizen, Marc Deloger, Pierre Gestraud, Gèrard Socié, Sebastián Amigorena, Olivier Lantz, Laurie Menger
Abstract
T cells. Together, these findings identify SOCS1 as a major intracellular negative checkpoint of adoptive T cell response, opening new possibilities to optimize CAR-T cell therapy composition and efficacy.
Topics & Concepts
Suppressor of cytokine signaling 1BiologyT cellCell biologyAdoptive cell transferCytotoxic T cellCytokineCell growthCD8Cancer researchImmunologyAntigenImmune systemCancerSuppressorIn vitroGeneticsCAR-T cell therapy researchCRISPR and Genetic EngineeringT-cell and B-cell Immunology