Pyridyl-Isonicotinoyl Hydrazone-Bridged Zn(II) Coordination Framework with Thiophenedicarboxylato Link: Structure, Biological Activity, and Electrical Conductivity
Manik Shit, Satyajit Halder, Arka Dey, Basudeb Dutta, Anjana Chanthapally, Kuladip Jana, Chittaranjan Sinha
Abstract
Multidimensional applicability of functional materials is one of the focal attractions in today’s scientific research. Highly stable and crystalline coordination polymers served as one of the active members in the club of multifunctional materials. Toward this concept, a 3-dimensional (3D) coordination framework, {[Zn 2 ( tdc ) 2 ( pcih ) 2 ] n } ( 1 ) ( tdc 2–, 2,5-thiophene dicarboxylate; pcih, pyridine-4-carboxaldehyde isonicotinoyl hydrazine), is designed and has been structurally well characterized by single crystal X-ray crystallography. One of the carboxylate groups of tdc 2– chelates to Zn(II), while the other carboxylato group (–COO) acts as bridging-O to neighboring Zn(II); the pcih serves as pyridyl-N bridging motif to two Zn(II) centers. The optical band gap, 3.83 eV (Tauc’s plot), implies probable semiconducting ability of the material. Interestingly, the device fabricated using compound 1 measures the electrical conductivity, 2.21 × 10 –5 S cm –1, and series resistance ( R s ), 807 Ω, at the dark phase, which are improved significantly to 6.36 × 10 –5 S cm –1 and 460 Ω, respectively, under illumination conditions. Isoniazid, used to synthesize pcih and hence the Zn(II) compound 1, is a medicine; so, the medicinal efficiency of 1 is checked by measuring the anticancer activity against MDA-MB-231, HeLa, HCT-116, and HepG2 cells. It is observed that drug efficacy is highest on MDA-MB-231 cells (IC 50: 19.43 ± 1.36 μM) than other cancer cells [IC 50: 24.43 ± 2.02 μM (HeLa), 26.06 ± 3.48 μM (HCT-116), and 44.28 ± 3.04 μM (HepG2)]. Therefore, the material has significant contribution in the area of energy and health toward the sustainable development goals.