A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity <i>In Vitro</i>
Qi Guo, Liyun Xu, Fusheng Tan, Yongjie Zhang, Junsheng Fan, Xinghai Wang, Zhemin Zhang, Bing Li, Haiqing Chu
Abstract
, with effects comparable to the anti-M. abscessus effects of linezolid both extracellularly and intracellularly. Contezolid did not antagonize the most frequently used anti-M. abscessus drugs, and preexposure to contezolid did not induce drug resistance. These results provide a novel approach to treating M. abscessus infections.
Topics & Concepts
Mycobacterium abscessusIn vitroLinezolidMicrobiologyMycobacteriumDrug resistanceMedicineAntibacterial agentAntibioticsNontuberculous mycobacteriaBiologyPharmacologyBacteriaBiochemistryGeneticsVancomycinStaphylococcus aureusMycobacterium research and diagnosisInfectious Diseases and MycologyTuberculosis Research and Epidemiology