Induction of Transmucosal Protection by Oral Vaccination with an Attenuated Chlamydia
Yihui Wang, Rongze He, Halah Winner, Marie‐Claire Gauduin, Nu Zhang, Cheng He, Guangming Zhong
Abstract
Chlamydia muridarum has been used to study chlamydial pathogenesis because it induces mice to develop hydrosalpinx, a pathology observed in C. trachomatis -infected women. We identified a C. muridarum mutant that is no longer able to induce hydrosalpinx.
Topics & Concepts
ChlamydiaHydrosalpinxChlamydia trachomatisBiologyChlamydialesVaccinationChlamydiaceaeImmunologyVirologyPathogenesisChlamydial infectionMutantMicrobiologyGeneticsInfertilityGenePregnancyReproductive tract infections researchCervical Cancer and HPV ResearchReproductive System and Pregnancy