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ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers

Ramesh Yelagandula, Karin Stecher, Maria Novatchkova, Luca Michetti, Georg Michlits, Jingkui Wang, Pablo Hofbauer, Gintautas Vainorius, Carina Pribitzer, Luke Isbel, Sasha Mendjan, Dirk Schübeler, Ulrich Elling, Julius Brennecke, Oliver Bell

2023Nature Cell Biology43 citationsDOIOpen Access PDF

Topics & Concepts

BiologyEnhancerEpigeneticsChromatinGeneticsTranscription factorGene silencingHeterochromatinCell biologyHaploinsufficiencyHistoneLineage (genetic)GenePhenotypeEpigenetics and DNA MethylationCRISPR and Genetic EngineeringGenetics and Neurodevelopmental Disorders
ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers | Litcius