Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways
Hao Li, Chengcheng Ma, Zhaoxia Li, Yanchao Wang, Xue Zhao, Mingxiao Yu, Hu Hou
Abstract
were studied by proteomics, and the effects of BIIP on OA through signaling pathways, such as NF-κB, Wnt/β-catenin and MAPK, were further explored at mRNA and protein levels. BIIP downregulated the expression of IL-6, RUNX2, NF-κB p65, HIF-2α, β-catenin and p-JNK, which may be the main factor leading to the prevention of OA. These results suggest that BIIP can be used as a novel potential substance of functional foods to exert chondroprotective action.
Topics & Concepts
OsteoarthritisWnt signaling pathwayMAPK/ERK pathwayCartilageMedial collateral ligamentCateninSignal transductionChemistryType II collagenNF-κBCancer researchMedicineCell biologyPharmacologyPathologyAnatomyBiologyBiochemistryAnterior cruciate ligamentAlternative medicineOsteoarthritis Treatment and MechanismsInflammatory mediators and NSAID effectsProtein Hydrolysis and Bioactive Peptides