Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
Philipp Schommers, Henning Gruell, Morgan E. Abernathy, My-Kim Tran, Adam S. Dingens, Harry B. Gristick, Christopher O. Barnes, Till Schoofs, Maike Schlotz, Kanika Vanshylla, Christoph Kreer, Daniela Weiland, Udo Holtick, Christof Scheid, Markus M. Valter, Marit J. van Gils, Rogier W. Sanders, Jörg Janne Vehreschild, Oliver A. Cornely, Clara Lehmann, Gerd Fätkenheuer, Michael S. Seaman, Jesse D. Bloom, Pamela J. Björkman, Florian Klein
Abstract
Env complex revealed that these characteristics are likely facilitated by a heavy-chain insertion and increased inter-protomer contacts. The ability of 1-18 to effectively restrict HIV-1 escape pathways provides a new option to successfully prevent and treat HIV-1 infection.
Topics & Concepts
BiologyViremiaVirologyAntibodyHuman immunodeficiency virus (HIV)Neutralizing antibodyPotencyViral replicationImmunologyVirusGeneticsIn vitroHIV Research and TreatmentMonoclonal and Polyclonal Antibodies ResearchImmune Cell Function and Interaction