OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes
Mengyang Wang, Xue Han, Tianxiang Yu, Minxiu Wang, Wu Luo, Chunpeng Zou, Xiuyun Li, Gao Li, Gaojun Wu, Yi Wang, Guang Liang
Abstract
Cardiomyocyte OTUD1 promotes pathological cardiac remodeling and dysfunction by deubiquitinating STAT3. These studies have highlighted a novel role of OTUD1 in hypertensive heart failure and identified STAT3 as a target of OTUD1 in mediating these actions.
Topics & Concepts
Deubiquitinating enzymeHeart failureFibrosisAngiotensin IIUbiquitinCardiac fibrosisCardiac function curveVentricular remodelingKnockout mouseMedicineCancer researchBiologyCell biologyInternal medicineReceptorGeneBiochemistryUbiquitin and proteasome pathwaysPeptidase Inhibition and AnalysisCardiac Fibrosis and Remodeling