LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia
Christian Henneberger, Lucie Bard, Aude Panatier, James R. Reynolds, Olga Kopach, Nikolay Medvedev, Daniel Minge, Michel K. Herde, Stefanie Anders, Igor Kraev, J Heller, Sylvain Rama, Kaiyu Zheng, Thomas P. Jensen, Inmaculada Sánchez-Romero, Colin J. Jackson, Harald Janovjak, Ole Petter Ottersen, Erlend A. Nagelhus, Stéphane H. R. Oliet, Michael G. Stewart, U. Valentin Nägerl, Dmitri A. Rusakov
Abstract
-dependent cascades in astrocytes. We have therefore uncovered a mechanism by which a memory trace at one synapse could alter signal handling by multiple neighboring connections.
Topics & Concepts
Long-term potentiationGlutamate receptorNeuroscienceNMDA receptorCofilinExcitatory postsynaptic potentialNeurotransmissionLTP inductionChemistryBiologyInhibitory postsynaptic potentialReceptorActin cytoskeletonBiochemistryCellCytoskeletonNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsNeural dynamics and brain function