The pulmonary effects of nickel-containing nanoparticles: cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms
Yiqun Mo, Yue Zhang, Qunwei Zhang
Abstract
, and the potential underlying mechanisms were also included. In addition, whether these adverse effects were induced by NPs themselves or Ni ions released from the NPs was also discussed. The extra-pulmonary effects of Ni-containing NPs were briefly mentioned. This review will provide us with a comprehensive view of the pulmonary effects of Ni-containing NPs and their underlying mechanisms, which will shed light on our future studies, including the urgency and necessity to produce engineering Ni-containing NPs with controlled and reduced toxicity, and also provide the scientific basis for developing nanoparticle exposure limits and policies.
Topics & Concepts
GenotoxicityCarcinogenCytotoxicityIn vivoCytotoxic T cellIn vitroChemistryLungCancer researchPharmacologyToxicityBiologyMedicineBiochemistryGeneticsInternal medicineOrganic chemistryNanoparticles: synthesis and applicationsAir Quality and Health ImpactsHeavy Metal Exposure and Toxicity