PI3K/AKT inhibition reverses R-CHOP resistance by destabilizing SOX2 in diffuse large B cell lymphoma
Jianfeng Chen, Xiaowen Ge, Wei Zhang, Peipei Ding, Yiqun Du, Qi Wang, Ling Li, Lan Fang, Yujing Sun, Pingzhao Zhang, Yuzhen Zhou, Long Zhang, Xinyue Lv, Luying Li, Xin Zhang, Qunling Zhang, Kai Xue, Hongyu Gu, Qun‐Ying Lei, Jiemin Wong, Weiguo Hu
Abstract
: The PI3K/AKT/SOX2 axis plays a critical role in R-CHOP resistance development and the pro-differentiation therapy against CSCs proposed in this study warrants further study in clinical trials for the treatment of resistant DLBCL.
Topics & Concepts
PI3K/AKT/mTOR pathwayDiffuse large B-cell lymphomaCHOPCancer researchProtein kinase BLymphomaChemistryMedicineBiologyInternal medicineCell biologySignal transductionUbiquitin and proteasome pathwaysRNA modifications and cancerCancer, Hypoxia, and Metabolism