Strategic delivery of rapamycin and ranibizumab with intravitreal hydrogel depot disrupts multipathway-driven angiogenesis loop for boosted wAMD therapy
Xi Jiang, Congyan Liu, Qun Zhang, Yanli Lv, Lu Chen, Wenting Su, Jing Zhou, Huangqin Zhang, Huiling Gong, Yuping Liu, Songtao Yuan, Yan Chen, Ding Qu
Topics & Concepts
RanibizumabPI3K/AKT/mTOR pathwayMacular degenerationAMPKAutophagyAngiogenesisChoroidal neovascularizationPharmacologyOxidative stressRabRetinalMedicineCancer researchChemistryCell biologyOphthalmologyBiologySignal transductionInternal medicineBevacizumabProtein kinase AKinaseBiochemistryApoptosisGTPaseChemotherapyRetinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis