POCl<sub>3</sub>/Sulfoxide-Promoted Synthesis of Indolizino[8,7-<i>b</i>]indoles
Xiao‐Hui Chen, Yun‐Meng Li, Xiang Huang, Hai‐Lei Cui
Abstract
A mild chlorocyclization of pyrrole-tethered indoles has been realized using POCl 3 as the chlorine source and tetramethylene sulfoxide as the promoter. A variety of chlorinated indolizino[8,7- b ]indole derivatives have been constructed efficiently under this reaction system in moderate to good yields (19 examples, up to 93% yield).
Topics & Concepts
Indole testSulfoxidePyrroleChemistryYield (engineering)ChlorineMedicinal chemistryDimethyl sulfoxideOrganic chemistryCombinatorial chemistryMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsAlkaloids: synthesis and pharmacology