Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis
Xiaofan Yang, Pingping Xue, Hongrui Chen, Meng Yuan, Yu Kang, Dominik Duscher, Hans‐Günther Machens, Zhenbing Chen
Abstract
: Collectively, our data revealed that miR-142a-5p was able to function as an important regulator of denervation-induced skeletal muscle atrophy by inducing mitochondrial dysfunction, mitophagy, and apoptosis via targeting MFN1. Our findings provide new insights into the mechanism of skeletal muscle atrophy following denervation and propose a viable target for therapeutic intervention in individuals suffering from muscle atrophy after peripheral nerve injury.
Topics & Concepts
MFN1MitophagyDenervationMuscle atrophyMFN2AtrophyGastrocnemius muscleMitochondrionSkeletal muscleInternal medicineSciatic nerveCell biologyEndocrinologyBiologymitochondrial fusionMedicineApoptosisAutophagyMitochondrial DNABiochemistryGeneMuscle Physiology and DisordersAutophagy in Disease and TherapyMitochondrial Function and Pathology