Mycobacterium tuberculosis (Mtb) lipid mediated lysosomal rewiring in infected macrophages modulates intracellular Mtb trafficking and survival
Kuldeep Singh Sachdeva, Manisha Goel, Malvika Sudhakar, Mansi Mehta, Raju Rajmani, Karthik Raman, Amit Singh, Varadharajan Sundaramurthy
Abstract
-infected macrophages and suggest that this altered lysosomal state protects host cell integrity and contributes to the containment of the pathogen.
Topics & Concepts
TFEBIntracellularBiologyIntracellular parasiteCell biologyPhagosomeLysosomeMycobacterium tuberculosisMicrobiologyPathogenMacrophagePhagocytosisIn vitroIn vivoTuberculosisBiochemistryEnzymePathologyBiotechnologyMedicineCalcium signaling and nucleotide metabolismLysosomal Storage Disorders ResearchAutophagy in Disease and Therapy