Treatment Strategies for Advanced Classical Hodgkin Lymphoma in the Times of Dacarbazine Shortage
Pallawi Torka, Eugene Przespolewski, Andrew M. Evens
Abstract
The shortage of dacarbazine (DTIC) has created an acute and unprecedented crisis in the management of patients with classical Hodgkin lymphoma, with DTIC being an essential component of doxorubicin, bleomycin, vinblastine, and DTIC (ABVD) and prior attempts at omitting DTIC from ABVD leading to substantial loss of efficacy. In this review, we discuss the strategies to manage classical Hodgkin lymphoma during the DTIC shortage and propose a treatment algorithm on the basis of fitness and ability to receive anthracyclines safely.
Topics & Concepts
DacarbazineABVDBleomycinVinblastineMedicineEconomic shortageHodgkin's lymphomaLymphomaHodgkin lymphomaOncologyChemotherapyInternal medicineVincristineLinguisticsPhilosophyCyclophosphamideGovernment (linguistics)Lymphoma Diagnosis and TreatmentChronic Lymphocytic Leukemia ResearchLung Cancer Treatments and Mutations