N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview
Gulraız Ahmad, Maria Sohail, Muhammad Bılal, Nasır Rasool, Muhammad Usman Qamar, Codrut Ciurea, Luigi Geo Marceanu, Cătalin Mișarca
Abstract
Viruses are a real threat to every organism at any stage of life leading to extensive infections and casualties. N-heterocycles can affect the viral life cycle at many points, including viral entrance into host cells, viral genome replication, and the production of novel viral species. Certain N-heterocycles can also stimulate the host’s immune system, producing antiviral cytokines and chemokines that can stop the reproduction of viruses. This review focused on recent five- or six-membered synthetic N-heterocyclic molecules showing antiviral activity through SAR analyses. The review will assist in identifying robust scaffolds that might be utilized to create effective antiviral drugs with either no or few side effects.