Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease
Lei Miao, Li Yang, Lisha Guo, Qiang‐Qiang Shi, Tengfei Zhou, Yang Chen, Huai Zhang, Hui Cai, Zhiwei Xu, Shuanying Yang, Hai Lin, Zhe Cheng, Ming-Yang Zhu, Nan Xu, Shuai Huang, Yawen Zheng, Giovanni Targher, Christopher D. Byrne, Yuping Li, Ming‐Hua Zheng, Chengshui Chen
Abstract
Background and Aims: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibrosis severity in MAFLD. Methods: In this cross-sectional study, we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020. All participants received a health check-up including measurement of anthropometric parameters, biochemical variables, liver ultrasonography, and spirometry. The severity of liver disease was assessed by the fibrosis (FIB)-4 score. Results: =0.004). The results remained unchanged when the statistical analyses was performed separately for men and women. Conclusions: MAFLD was significantly associated with a greater impairment of lung function parameters than NAFLD.