How Biofilm Growth Affects Candida-Host Interactions
Emily F. Eix, Jeniel E. Nett
Abstract
Candida spp. proliferate as surface-associated biofilms in a variety of clinical niches. These biofilms can be extremely difficult to eradicate in healthcare settings. Cells within biofilm communities grow as aggregates and produce a protective extracellular matrix, properties that impact the ability of the host to respond to infection. Cells that disperse from biofilms display a phenotype of enhanced pathogenicity. In this review, we highlight host-biofilm interactions for Candida, focusing on how biofilm formation influences innate immune responses.
Topics & Concepts
BiofilmMicrobiologyBiologyHost (biology)Innate immune systemImmune systemExtracellular polymeric substanceExtracellular matrixBacteriaImmunologyCell biologyEcologyGeneticsAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentFungal Infections and Studies