A novel radiolabelled salmochelin derivative for bacteria-specific PET imaging: synthesis, radiolabelling and evaluation
Renato Margeta, Sonja Schelhaas, Sven Hermann, Michael Schäfers, Silke Niemann, Andreas Faust
Abstract
A 68 Ga-labelled salmochelin-related PET-radiotracer was developed based on a Trojan horse strategy by targeting the siderophore mediated iron-transport for specific imaging of bacterial infection.
Topics & Concepts
BiodistributionBacteriaEscherichia coliPet imagingChemistryImaging agentDerivative (finance)RadiochemistryCombinatorial chemistryPositron emission tomographyBiochemistryIn vivoBiologyNuclear medicineMedicineIn vitroGeneticsGeneBiotechnologyFinancial economicsEconomicsBacterial Infections and VaccinesAmoebic Infections and TreatmentsCancer Research and Treatments