Coeloglossum viride var. bracteatum extract attenuates staurosporine induced neurotoxicity by restoring the FGF2-PI3K/Akt signaling axis and Dnmt3
Zheping Cai, Chang Cao, Zhe Guo, Yun Yu, Si-Jia Zhong, Rui‐Yuan Pan, Haowen Liang, Rongfeng Lan, Xiao‐Yan Qin
Abstract
DNA methylation. The Dnmts inhibitor 5-azacytidine impaired CE-mediated restoration of Dnmt3 or CaM, as well as the transition of DNA methylation status on the Dnmt3 promoter. These results reveal potential mechanisms that could facilitate the study and application of CE as a neuroprotective agent.
Topics & Concepts
StaurosporineNeuroprotectionPI3K/AKT/mTOR pathwayNeurotoxicityPharmacologyLY294002BiologyProtein kinase BCell biologyBiochemistryChemistryToxicitySignal transductionProtein kinase COrganic chemistryBiological and pharmacological studies of plantsPlant Molecular Biology ResearchEpigenetics and DNA Methylation