Synthesis, characterization,<i>in silico</i>molecular docking, and antibacterial activities of some new nitrogen-heterocyclic analogues based on a<i>p</i>-phenolic unit
Abdel Haleem M. Hussein, Abu‐Bakr A. A. M. El‐Adasy, Ahmed M. M. El‐Saghier, M. Olish, Aboubakr H. Abdelmonsef
Abstract
and molecular docking study findings suggested that the compounds 6a and 6b (with pyrimidine moiety, amide linkage, and phenolic substrate) might be potent bacterial flavohemoglobin (flavoHB) inhibitors and they could set a promising starting point for future design of antibacterial agents.
Topics & Concepts
ChemistryMalononitrilePyrazoleEthyl chloroacetateAntibacterial activityThioureaOrganic chemistryThiazoleCombinatorial chemistryStereochemistryBacteriaHydrateCatalysisGeneticsBiologySynthesis and biological activityFree Radicals and AntioxidantsHemoglobin structure and function