Copper‐Catalyzed Dynamic Kinetic C−P Cross‐Coupling/Cyclization for the Concise Asymmetric Synthesis of Six‐, Seven‐ and Eight‐Membered<i>P</i>‐Stereogenic Phosphorus Heterocycles
Yanli Li, Xiao Jin, Peng Liu, Haijuan Zhang, Xiuling Yu, Yanjuan Liu, Baixue Liu, Wenqiang Yang
Abstract
A copper-catalyzed asymmetric aryl C-P cross-coupling/cyclization reaction was successfully developed via dynamic kinetic asymmetric transformation (DYKAT) under mild conditions. This study provides a general and simple method for the catalytic enantioselective synthesis of stable six-, seven- and eight-membered P-stereogenic phosphorus heterocycles with excellent enantioselectivities and moderate to high yields. One-pot gram-scale asymmetric synthesis of the P-stereogenic P-heterocycle from commercially available materials was also successfully accomplished with excellent enantioselectivity and high yield.
Topics & Concepts
StereocenterEnantioselective synthesisCatalysisYield (engineering)ChemistryPhosphorusArylCopperCombinatorial chemistryStereochemistryOrganic chemistryMaterials scienceAlkylMetallurgySynthetic Organic Chemistry MethodsAsymmetric Hydrogenation and CatalysisOrganophosphorus compounds synthesis