Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus
Sriram Vaidyanathan, Ron Baik, Lü Chen, Dawn T. Bravo, Carlos J. Suarez, Shayda M. Abazari, Ameen A. Salahudeen, Amanda M. Dudek, Christopher A. Teran, Timothy Davis, Ciaran M. Lee, Gang Bao, Scott H. Randell, Steven E. Artandi, Jeffrey J. Wine, Calvin J. Kuo, Tushar Desai, Jayakar V. Nayak, Zachary M. Sellers, Matthew H. Porteus
Topics & Concepts
Cystic fibrosis transmembrane conductance regulatorCystic fibrosisBiologyCRISPRGenetic enhancementMutationStem cellMolecular biologyGeneticsGeneImmunologyCystic Fibrosis Research AdvancesEnergy Harvesting in Wireless NetworksCRISPR and Genetic Engineering