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Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer

Qiaoling Liang, Shi Zhang, Shi Zhang, Xiaoqun Zhou, Nur Syamimi Ariffin, Jian-Hua Wei, Chengyi Shi, Xian‐Li Ma, Ye Zhang, Ri-Zhen Huang, Ri-Zhen Huang

2024Bioorganic Chemistry15 citationsDOI

Topics & Concepts

ChemistryTriple-negative breast cancerCancer researchApoptosisDocking (animal)Carbonic anhydraseCancer cellProgrammed cell deathBreast cancerInducerIntracellularCancerEnzymeBiochemistryBiologyGeneGeneticsNursingMedicineEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases
Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer | Litcius