Voltammetric Determination of Isoniazid in the Presence of Acetaminophen Utilizing MoS2-Nanosheet-Modified Screen-Printed Electrode
Somayeh Tajik, Zahra Dourandish, Fariba Garkani Nejad, Abbas Aghaei Afshar, Hadi Beitollahi
Abstract
NSs-SPE) aimed at detecting isoniazid (INZ) in the presence of acetaminophen (AC). According to analysis, an impressive catalytic performance was found for INZ and AC electro-oxidation, resulting in an appreciable peak resolution (~320 mV) for both analytes. Chronoamperometry, differential pulse voltammetry (DPV), linear sweep voltammogram (LSV), and cyclic voltammetry (CV) were employed to characterize the electrochemical behaviors of the modified electrode for the INZ detection. Under the optimal circumstances, there was a linear relationship between the peak current of oxidation and the various levels of INZ (0.035-390.0 µM), with a narrow limit of detection (10.0 nM). The applicability of the as-developed sensor was confirmed by determining the INZ and AC in tablets and urine specimens, with acceptable recoveries.