The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells
Eishu Hirata, Kojiro Ishibashi, Shinji Kohsaka, Keiko Shinjo, Shinya Kojima, Yutaka Kondo, Hiroyuki Mano, Seiji Yano, Etsuko Kiyokawa, Erik Sahai
Abstract
. Our results demonstrate that transcriptional changes triggered by DNMT1 suppression is a key step for cancer cells to survive in the brain microenvironment and that they also restrict cancer cell proliferation. The dual consequences of DNMT1 suppression can explain the persistence of indolent cancer cells in the brain microenvironment.
Topics & Concepts
DNMT1Cancer researchCancer cellTumor microenvironmentCancerBiologyBrain metastasisMetastasisCell cycleCell biologyChemistryGene expressionDNA methylationGeneGeneticsTumor cellsEpigenetics and DNA MethylationBrain Metastases and TreatmentGlioma Diagnosis and Treatment