A core/shell nanogenerator achieving pH-responsive nitric oxide release for treatment of infected diabetic wounds
Yaming Zhou, Yanjie Jiang, Cai Jingfeng, Jiaping Wang, Shuo Li, Miao Wang, Xi Zhou, Xiumin Wang, Xueqin Zhao, Lei Ren
Abstract
, this nanogenerator can achieve a responsive and accelerated release of nitric oxide from ISDN through enzyme-mimicking redox processes that involve CuS nanoparticles and then inactivate biofilm bacteria through the pathways of oxidative stress and disruption of adenosine triphosphate (ATP)-related energy metabolism. Moreover, after eliminating the infection, the pH-responsive release of nitric oxide can promote the proliferation of blood vessels and tissue regeneration and accelerate diabetic wound closure. This study expands the use of nitric oxide donors in wound treatment by developing the enzyme-mimicking release strategy, and the pH-responsive core/shell nanogenerator is promising for a variety of anti-infection therapeutic applications.