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Deletion of the <i>lon</i> gene augments expression of <i>Salmonella</i> Pathogenicity Island (SPI)-1 and metal ion uptake genes leading to the accumulation of bactericidal hydroxyl radicals and host pro-inflammatory cytokine-mediated rapid intracellular clearance

Perumalraja Kirthika, Amal Senevirathne, Vijayakumar Jawalagatti, SungWoo Park, John Hwa Lee

2020Gut Microbes41 citationsDOIOpen Access PDF

Abstract

mutant is a result of disrupted bacterial intracellular equilibrium and rapid activation of cytokine expression leading to bacterial lysis.

Topics & Concepts

VirulenceBiologyMicrobiologyMutantPathogenicity islandGeneOxidative stressIntracellularSalmonellaSalmonella entericaGene expressionBacteriaCell biologyBiochemistryGeneticsSalmonella and Campylobacter epidemiologyVibrio bacteria research studiesTrace Elements in Health
Deletion of the <i>lon</i> gene augments expression of <i>Salmonella</i> Pathogenicity Island (SPI)-1 and metal ion uptake genes leading to the accumulation of bactericidal hydroxyl radicals and host pro-inflammatory cytokine-mediated rapid intracellular clearance | Litcius