Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling
Hongchang Li, Wen Xu, Zhihua Xia, Weiyan Liu, Gaofeng Pan, Junbin Ding, Jindong Li, Jianfa Wang, Xiaofeng Xie, Daowen Jiang
Abstract
<0.01). Conclusively, silencing of hsa_circ_0000199 enhanced TNBC chemo-sensitivity by promoting miR-206/miR-613 expression and deactivating PI3K/Akt/mTOR signaling, which was conducive to improving chemotherapeutic efficacy of TNBC patients.
Topics & Concepts
PI3K/AKT/mTOR pathwayTriple-negative breast cancerCancer researchProtein kinase BBreast cancerChemistryCancerMedicineBiologySignal transductionCell biologyInternal medicineCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation