Independent Effects of HIV and Antiretroviral Therapy on the Oral Microbiome Identified by Multivariate Analyses
Clifford J. Beall, Elizabeth A. Lilly, Carolina Granada, Kelly Treas, Kenneth R. Dubois, Shahr B. Hashmi, José A. Vázquez, Michael E. Hagensee, Ann L. Griffen, Eugene J. Leys, Paul L. Fidel
Abstract
(preexposure prophylaxis [PrEP]) subjects before and after the initiation of ART. While we report independent significant effects of HIV and ART on the oral microbiome, we conclude that their influence is similar to that of the clinical variables but collectively modest overall.
Topics & Concepts
Antiretroviral therapyMicrobiomeMultivariate statisticsHuman immunodeficiency virus (HIV)Multivariate analysisOral MicrobiomeMedicineComputational biologyVirologyData scienceBiologyComputer scienceBioinformaticsViral loadInternal medicineMachine learningHIV/AIDS oral health manifestationsOral microbiology and periodontitis researchOral and gingival health research