Control over Stereogenic N–N Axes by Pd-Catalyzed 5-endo-Hydroaminocyclizations
Christof Sparr, Valeriia Hutskalova
Abstract
Abstract A novel approach for the stereoselective construction of N–N atropisomeric compounds by a Pd-catalyzed 5-endo-hydroaminocyclization is described herein. A broad range of bisheterocycles , connected by a configurationally stable N–N stereogenic axis, were prepared with catalyst control in enantioenriched form.
Topics & Concepts
StereocenterChemistryCatalysisStereoselectivityStereochemistryCombinatorial chemistryEnantioselective synthesisOrganic chemistryAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis