Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease
James T. Brewster, Grégory Thiabaud, Peter Harvey, Hadiqa Zafar, James F. Reuther, Simone Dell’Acqua, Rachel M. Johnson, Harrison D. Root, Pedro Metola, Alan Jasanoff, Luigi Casella, Jonathan L. Sessler
Abstract
Sessler et al. have studied manganese(II) texaphyrin as a catalytic metalloantioxidant theranostic agent for the detection of Ab aggregates. A series of in vitro and in vivo analyses allowed for the inference that metallotexaphyrins could be used for MRI-based detection of Ab biomarkers. In vitro and cellularbased assays coupled with mechanistic analysis demonstrated an efficacious protective effect against oxidative and nitrative damage. The present results could thus guide future efforts in developing new theranostic modalities for use in neurodegenerative disease.