RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity
Wenwen Wang, Mutian Jia, Chunyuan Zhao, Zhongxia Yu, Hui Song, Ying Qin, Wei Zhao
Abstract
deficiency enhances RNA virus-triggered innate immune responses and attenuates viral replication. Thus, our results uncover a previously unknown mechanism for the control of DDX3X activity and suggest RNF39 as a priming intervention target for diseases caused by aberrant RLR activation.
Topics & Concepts
UbiquitinUbiquitin ligaseCell biologyImmunityBiologyVirologyChemistryGeneticsImmune systemGeneinterferon and immune responsesImmune Cell Function and InteractionViral Infections and Immunology Research