Organocatalytic radical relay trifunctionalization of unactivated alkenes by a combination of cyano migration and alkylacylation
Jingyi Wang, Yuchan Wang, Jibin Li, Zexuan Wei, Jie Feng, Ding Du
Abstract
-heterocyclic carbene organocatalytic three-component radical relay trifunctionalization of unactivated alkenes through the combination of remote 1,4-cyano migration and alkylacylation was reported. This protocol features mild reaction conditions, readily available materials, excellent regioselectivity, and capability of late-stage functionalization.
Topics & Concepts
RegioselectivitySurface modificationRelayCarbeneChemistryCombinatorial chemistryRadicalComponent (thermodynamics)CatalysisOrganic chemistryPower (physics)Quantum mechanicsPhysicsThermodynamicsPhysical chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions