Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains
Tongqing Zhou, Yaroslav Tsybovsky, Jason Gorman, Micah Rapp, Gabriele Cerutti, Gwo‐Yu Chuang, Phinikoula S. Katsamba, Jared M. Sampson, Arne Schön, Jude Bimela, Jeffrey C. Boyington, Alexandra F. Nazzari, Adam S. Olia, Wei Shi, Mallika Sastry, Tyler Stephens, Jonathan Stuckey, I‐Ting Teng, Pengfei Wang, Shuishu Wang, Baoshan Zhang, Richard A. Friesner, David D. Ho, John R. Mascola, Lawrence Shapiro, Peter D. Kwong
Topics & Concepts
BiologyEndosomeSpike (software development)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Cell biologyReceptorCoronavirus disease 2019 (COVID-19)Spike ProteinPlasma protein binding2019-20 coronavirus outbreakBiophysicsComputational biologyVirologyGeneticsComputer scienceDiseaseInfectious disease (medical specialty)Software engineeringOutbreakMedicinePathologySARS-CoV-2 and COVID-19 ResearchLipid Membrane Structure and BehaviorCell death mechanisms and regulation