3D-bioprinting ready-to-implant anisotropic menisci recapitulate healthy meniscus phenotype and prevent secondary joint degeneration
Ye Sun, Yuxin Zhang, Qiang Wu, Feng Gao, Yongzhong Wei, Yimin Ma, Wenbo Jiang, Kerong Dai
Abstract
3D-bioprinted TCM meniscus not only restored the anisotropy of native healthy meniscus with PBV infiltration and better shape retention, but better maintained joint function and prevented secondary joint degeneration, which provided a new strategy for the clinical treatment of meniscus injury-related joint degenerative diseases.
Topics & Concepts
MeniscusPhenotypeDegeneration (medical)OsteoarthritisKnee JointMedicinePathologyChemistrySurgeryAlternative medicineBiochemistryGeneIncidence (geometry)PhysicsOpticsKnee injuries and reconstruction techniquesBone Tissue Engineering MaterialsPolymer Surface Interaction Studies