Mechanistic Differences of Activation of Rac1<sup>P29S</sup> and Rac1<sup>A159V</sup>
Simge Senyuz, Hyunbum Jang, Ruth Nussinov, Özlem Keskin, Attila Gürsoy
Abstract
-GTP adopts a Ras state 2 like conformation, where both switch regions are in closed conformation and Thr35 forms a hydrogen bond with the nucleotide.
Topics & Concepts
RAC1ChemistryBiochemistrySignal transductionProtein Structure and DynamicsNeuroscience and Neuropharmacology ResearchIon channel regulation and function