Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
Cegui Hu, Wen Qiao, Xiang Li, Zhikun Ning, Jiang Liu, Sumiya Dalangood, Hanjun Li, Xiang Yu, Zhen Zong, Zhenke Wen, Jun Gui
Topics & Concepts
mTORC1Immune systemBiologyFGF21Cytotoxic T cellCD8Cancer researchAcquired immune systemImmune checkpointCancer immunotherapyTumor progressionImmunotherapyCell biologyCancerPI3K/AKT/mTOR pathwayImmunologySignal transductionFibroblast growth factorReceptorBiochemistryGeneticsIn vitroFibroblast Growth Factor ResearchEpigenetics and DNA MethylationKruppel-like factors research