Chemokine receptor CXCR3 is required for lethal brain pathology but not pathogen clearance during cryptococcal meningoencephalitis
Jintao Xu, Lori M. Neal, Anutosh Ganguly, Jessica L. Kolbe, Jessica C. Hargarten, Waleed Elsegeiny, Christopher Hollingsworth, Xiumiao He, Mike Ivey, Rafael Lopez, Jessica Zhao, Benjamin M. Segal, Peter R. Williamson, Michal A. Olszewski
Abstract
T cells drive lethal CNS pathology but are not required for fungal clearance during CM. The CXCR3 pathway shows potential as a therapeutic target or for biomarker discovery to limit CNS inflammatory damages.
Topics & Concepts
CXCR3ImmunologyCentral nervous systemBiologyChemokine receptorChemokineMeningoencephalitisAdoptive cell transferPathologyMedicineT cellInflammationNeuroscienceImmune systemFungal Infections and StudiesAntifungal resistance and susceptibilityCytomegalovirus and herpesvirus research