Novel hybrids of thiazolidinedione-1,3,4-oxadiazole derivatives: synthesis, molecular docking, MD simulations, ADMET study,<i>in vitro</i>, and<i>in vivo</i>anti-diabetic assessment
Mahendra Gowdru Srinivasa, Jagdish Gopal Paithankar, Sumit Birangal, Aravinda Pai, Vasudev Baburaya Pai, Shridhar N. Deshpande, B. C. Revanasiddappa
Abstract
studies have shown that compounds 5a, 5b, and 5j lower glucose levels in Drosophila. These compounds could be further developed in the future to produce a new class of antidiabetic agents.
Topics & Concepts
ThiazolidinedioneOxadiazoleIn vivoIn vitroChemistryDocking (animal)Combinatorial chemistryPharmacologyBiochemistryMedicineDiabetes mellitusOrganic chemistryBiologyEndocrinologyType 2 diabetesBiotechnologyNursingSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic Compounds