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Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer’s disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation

Daniela Corrêa Santos, Ruan R. Henriques, Marcos Antônio Lopes, André Borges Farias, Thayssa Lisboa do Couto Nogueira, João Victor Fernandes Quimas, Nelilma Correia Romeiro, Leandro Louback da Silva, Andréa Luzia F. de Souza

2020Bioorganic & Medicinal Chemistry44 citationsDOI

Topics & Concepts

ChemistryAcetylcholinesteraseMyeloperoxidaseDPPHAntioxidantHydrazideChelationDocking (animal)AchéRadicalEnzymeStereochemistryHydrazoneBiochemistryOrganic chemistryInternal medicineInflammationNursingMedicineCholinesterase and Neurodegenerative DiseasesSynthesis and biological activityFree Radicals and Antioxidants
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer’s disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation | Litcius