A contact-polymerizable hemostatic powder for rapid hemostasis
Jia Wang, Cheng Li, Wei Zhang, Weimin Huang, Zhiqiang Liu, Rui Shi, Shiyuan Wang, Shan Liu, Weiguo Shi, Yun‐Lan Li, Liang Xu
Abstract
, even in a rat model with a weakened native hemostatic capacity. In addition, the poly-CA-PEG-CA gel could be rapidly biodegraded by ester bond hydrolysis. Notably, a cysteamine (CS)-containing solution could accelerate the degradation rate, endowing the gel with an on-demand removal property. This hemostatic powder not only can be used to efficiently control bleeding in emergency scenarios, but it can also allow nontraumatic re-exposure of wounds during subsequent surgical care. These properties make the CA-PEG-CA powder a promising candidate to act as a multifunctional wound care agent for first aid.
Topics & Concepts
Hemostatic AgentHemostasisPolymerizationAdhesiveCyanoacrylateChemistryWound careEthylene glycolPlateletHydrolytic degradationPEG ratioAdhesionHydrolysisPolymerSurgeryOrganic chemistryMedicineLayer (electronics)EconomicsImmunologyFinanceHemostasis and retained surgical itemsSurgical Sutures and AdhesivesTrauma, Hemostasis, Coagulopathy, Resuscitation