BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023
Anahita Fathi Kazerooni, Nastaran Khalili, Xinyang Liu, Debanjan Haldar, Zhifan Jiang, Anna Zapaishchykova, Julija Pavaine, Lubdha M. Shah, Blaise V. Jones, Nakul Sheth, Sanjay P. Prabhu, Aaron S. McAllister, Wenxin Tu, Khanak Nandolia, Andres Fernandez Rodriguez, Ibraheem S Shaikh, Mariana Sanchez-Montano, Hollie Anne Lai, Maruf Adewole, Jake Albrecht, Udunna Anazodo, Hannah Anderson, Syed Muhammed Anwar, Alejandro Aristizábal, Sina Bagheri, Ujjwal Baid, Timothy Bergquist, Austin J. Borja, Evan Calabrese, Verena Chung, Gian-Marco Conte, James A. Eddy, Ivan Ezhov, Ariana Familiar, Keyvan Farahani, Deep Gandhi, Anurag Gottipati, Shuvanjan Haldar, Juan Eugenio Iglesias, Anastasia Janas, Elaine Elaine, Alexandros Karargyris, Hasan Kassem, Neda Khalili, Florian Kofler, Dominic LaBella, Koen Van Leemput, Hongwei Li, Nazanin Maleki, Zeke Meier, Bjoern Menze, Ahmed W. Moawad, Sarthak Pati, Marie Piraud, Tina Young Poussaint, Zachary J. Reitman, Jeffrey D. Rudie, Rachit Saluja, Micah Sheller, Russell Takeshi Shinohara, Karthik Viswanathan, Chunhao Wang, Benedikt Wiestler, Walter F. Wiggins, Christos Davatzikos, Phillip B. Storm, Miriam Bornhorst, Roger Packer, Trent R. Hummel, Peter de Blank, Lindsey M. Hoffman, Mariam Aboian, Ali Nabavizadeh, Jeffrey B. Ware, Benjamin H. Kann, Brian Rood, Adam J. Resnick, Spyridon Bakas, Arastoo Vossough, Marius George Linguraru
Abstract
Pediatric central nervous system tumors are the leading cause of cancer-related deaths in children. The five-year survival rate for high-grade glioma in children is less than 20%. The development of new treatments is dependent upon multi-institutional collaborative clinical trials requiring reproducible and accurate centralized response assessment. We present the results of the BraTS-PEDs 2023 challenge, the first Brain Tumor Segmentation (BraTS) challenge focused on pediatric brain tumors. This challenge utilized data acquired from multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. BraTS-PEDs 2023 aimed to evaluate volumetric segmentation algorithms for pediatric brain gliomas from magnetic resonance imaging using standardized quantitative performance evaluation metrics employed across the BraTS 2023 challenges. The top-performing AI approaches for pediatric tumor analysis included ensembles of nnU-Net and Swin UNETR, Auto3DSeg, or nnU-Net with a self-supervised framework. The BraTS-PEDs 2023 challenge fostered collaboration between clinicians (neuro-oncologists, neuroradiologists) and AI/imaging scientists, promoting faster data sharing and the development of automated volumetric analysis techniques. These advancements could significantly benefit clinical trials and improve the care of children with brain tumors.