Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses
Rahul Kumar, Sahil Mishra, Shreya, Sushil K. Maurya
Abstract
) computational approach. From the beginning, viral replication has been the main focus for any antiviral drug development for viral diseases, including HCV, influenza virus, zika virus, norovirus, measles, dengue virus, and coronaviruses. This review lists the nucleoside, nucleotide, and non-nucleoside RdRp inhibitor analogues of various viral diseases that may be evaluated for drug development to treat COVID-19.
Topics & Concepts
VirologyRNA polymeraseRNA-dependent RNA polymeraseBiologyPolymeraseDruggabilityAntiviral drugRNARNA virusVirusGeneGeneticsSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyViral Infections and Immunology Research